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Integrase Inhibitors |
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Key Management Information |
| Direct Links to Integrase Inhibitor Info | |
| Key Points | |
| Generic | Brand |
| Dolutegravir | Tivicay |
| Raltegravir | Isentress |
| Key Principles of Integrase Inhibitors |
| The integrase inhibitors represent a
new class of antiretroviral therapy which became available as of October
2007 and again in a coformulation in late 2012. This drug class has proven efficacy against multidrug-resistant
HIV and is approved in the case of raltegravir for treatment-experienced patients. This class
of drugs acts by inhibiting the HIV integrase enzyme. The HIV
integrase enzyme allows for insertion of HIV DNA into host cell DNA.
Inhibition of this process results in termination of the reproductive
cycle of HIV. Like any other class of drugs, the integrase inhibitors must be administered with other antiretrovirals that are genotypically and phenotypically active against HIV.
The integrase inhibitors with the exception of dolutegravir seem to have a low barrier to resistance which emphasizes the principle of using the integrase inhibitors with other fully-active antiretrovirals. |
| Click HERE to go to Prescribing Information for raltegravir |
| Links to Antiretroviral Sections |
| Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI) |
| AZT | ddI | d4T | 3TC | ABC | FTC | TDF ||| Coformulation NRTI: Combivir | Trizivir | Epzicom | Truvada |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) |
| efavirenz | nevirapine | delavirdine | etravirine | rilpivirine |
| Protease Inhibitors (PI) | Boosted Protease Inhibitors |
| saquinavir | indinavir | ritonavir | nelfinavir | lopinavir + ritonavir | atazanavir | fosamprenavir | tipranavir |
| Co-receptor Inhibitors |
| maraviroc |
| Fusion Inhibitors |
| enfuvirtide |
| Integrase Inhibitors |
| raltegravir | elvitegravir | dolutegravir |
| Antiretroviral Metabolic Inhibitors |
| cobicistat | ritonavir |
| Coformulations |
| Atripla (efavirenz/tenofovir/emtricitabine) | Complera (rilpivirine/tenofovir/emtricitabine) | Stribild (elvitegravir/cobicistat/tenofovir/emtricitabine) |
Updated 11/10/2013