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zidovudine - lamivudine - abacavir [Trizivir] |
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Detailed Prescribing Information |
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October 2005 |
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Trizivir A combination of zidovudine + lamivudine + abacavir |
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| Forms Available | 300 mg zidovudine / 150 mg lamivudine in tablets / 300 mg abacavir in tablets |
| Dosing | 1 tablet twice a day |
| Renal dosing: not recommended | |
| Hepatic dosing: not recommended | |
| Food dependence | This medication is best taken on an empty stomach. |
| Adverse Effects | Same as zidovudine plus lamivudine plus abacavir |
| Interactions | Same as zidovudine plus lamivudine plus abacavir |
| Suggested lab follow-up | Monthly CBC x 3 months, then q3months if stable |
| Warning |
5% incidence of abacavir hypersensitivity
(see abacavir above)
Rare lactic acidosis and hepatic
steatosis. |
| Contraindication | Previous abacavir hypersensitivity |
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Suggested administration protocol |
Click HERE to review abacavir administration protocol |
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Suggested Usage |
Do not use in combination with
lamivudine,
emtricitabine,
Truvada,
Epzicom,
or Combivir
due to identical mechanism of action or duplication of
lamivudine dosing. Do not use Trizivir with stavudine due to antagonism with the zidovudine component. |
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Complete prescribing information |
Trizivir Prescribing Info |
| Links to Antiretroviral Sections (click on anything) |
| Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI) |
| AZT | ddC | ddI | d4T | 3TC | ABC | FTC | TDF | Combivir | Trizivir | Epzicom | Truvada |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) |
| efavirenz | nevirapine | delavirdine |
| Protease Inhibitors (PI) | Boosted Protease Inhibitors |
| saquinavir | indinavir | ritonavir | nelfinavir | amprenavir | lopinavir + ritonavir | atazanavir | fosamprenavir | tipranavir |
| Fusion Inhibitors |
| enfuvirtide |
Updated 10.25.2005
1. Renal dosing information from: Ian R.
McNicholl & Rudolph A. Rodriguez, MD, Dosing of Antiretroviral Drugs in Renal
Insufficiency and Hemodialysis, May 2004
http://hivinsite.ucsf.edu/InSite?page=md-rr-18