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Combivir |
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Detailed Prescribing Information |
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July 2006 |
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Combivir A combination of zidovudine + lamivudine |
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| Forms Available | 300 mg zidovudine / 150 mg lamivudine in tablets |
| Dosing | 1 tablet twice a day |
| Renal dosing: not recommended | |
| Hepatic dosing: not recommended | |
| Food dependence | This medication is best taken on an empty stomach. |
| Adverse Effects |
Same as
zidovudine plus
lamivudine
Mainly bone marrow suppression (leukopenia,
granulocytopenia, megaloblastic anemia,) nausea, headaches due to zidovudine |
| Interactions | Same as zidovudine plus lamivudine |
| Suggested lab follow-up |
Monthly CBC, comprehensive biochemical profile
for 3 months, then every 3 months if
stable Check serum lactic acid for symptoms of lactic acidosis (weakness, nausea, muscle aches, anion gap acidosis) |
| Warning |
Rare lactic acidosis and hepatic
steatosis. Use cautiously in patients with pre-existing anemia Possible flare of chronic hepatitis B if Combivir is discontinued suddenly. |
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Suggested Usage |
Do not use in combination with
lamivudine,
emtricitabine,
Truvada,
Epzicom,
Atripla, or Trizivir
due to identical mechanism of action or duplication of
lamivudine dosing or action. Do not use Combivir with stavudine due to antagonism with the zidovudine component of Combivir. Do not discontinue abruptly in patients with chronic hepatitis B without consideration of continuation of lamivudine or some other agent active against hepatitis B. |
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Complete prescribing information |
http://www.combivir.com |
| Links to Antiretroviral Sections (click on anything) |
| Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI) |
| AZT | ddC | ddI | d4T | 3TC | ABC | FTC | TDF | Combivir | Trizivir | Epzicom | Truvada | Atripla |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) |
| efavirenz | nevirapine | delavirdine |
| Protease Inhibitors (PI) | Boosted Protease Inhibitors |
| saquinavir | indinavir | ritonavir | nelfinavir | amprenavir | lopinavir + ritonavir | atazanavir | fosamprenavir | tipranavir | darunavir |
| Fusion Inhibitors |
| enfuvirtide |
Updated 7.14.2006
1. Renal dosing information from: Ian R.
McNicholl & Rudolph A. Rodriguez, MD, Dosing of Antiretroviral Drugs in Renal
Insufficiency and Hemodialysis, May 2004
http://hivinsite.ucsf.edu/InSite?page=md-rr-18
